Cellular immune response studies in bancroftian filariasis
Identifieur interne : 00B916 ( Main/Exploration ); précédent : 00B915; suivant : 00B917Cellular immune response studies in bancroftian filariasis
Auteurs : J. Regunathan [Inde] ; K. Jayaraman [Inde] ; P. Kaliraj [Inde]Source :
- Journal of Helminthology [ 0022-149X ] ; 1997-09.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Filarioses, Lymphocytes T.
- isolement et purification : Antigènes d'helminthe.
- pharmacologie : Phytohémagglutinine.
- sécrétion : Interleukine-1.
- Activation des lymphocytes, Animaux, Brugia malayi, Humains, Immunité cellulaire.
English descriptors
- KwdEn :
- MESH :
- chemical , isolation & purification : Antigens, Helminth.
- immunology : Filariasis, T-Lymphocytes.
- chemical , pharmacology : Phytohemagglutinins.
- chemical , secretion : Interleukin-1.
- Animals, Brugia malayi, Humans, Immunity, Cellular, Lymphocyte Activation.
Abstract
An attempt was made to identify the filarial specific antigens that are capable of inducing immune response in human filariasis. Lymphocytes were taken from three clinically defined groups living in an endemic area in Madras, namely microfilaraemic (MF) subjects with microfilariae in their blood smear without any clinical symptoms, chronic pathology (CP) individuals with lymphangitis or lymphadenitis in combination with a history of recurrent filarial fevers or lymphoedema, and endemic normals (EN) subjects without microfilariae nor any clinical symptoms of pathology. Lymphocytes from the three groups responded with no significant difference (P = 0.21) in their proliferative index to PPD and PHA, although lymphocytes from MF individuals showed significantly (P < 0.001) less proliferative index to Brugia malayi antigen (BMA) than the CP and EN subjects. This antigen specific cellular unresponsiveness seen in MF patients was not reversed by the addition of recombinant IL-lα, IL-1β, and IFN-γ, but the addition of sera from EN individuals seemed to restore this unresponsiveness (P < 0.001). The peripheral blood mononuclear cells from MF patients secreted more IL-1 in response to BMA induction than the same from CP and EN individuals. A 58 kDa recombinant protein isolated from a Wuchereria bancrofti genomic library (58 kDa) had mounted a higher proliferative response to lymphocytes from all three groups compared to BMA (P < 0.001) indicating the possible use of recombinant filarial protein to mount immunological responses in filarial patients.
Url:
DOI: 10.1017/S0022149X00016047
Affiliations:
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Regunathan</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Biotechnology, Anna University, Madras 600 025</wicri:regionArea><wicri:noRegion>Madras 600 025</wicri:noRegion></affiliation></author><author><name sortKey="Jayaraman, K" sort="Jayaraman, K" uniqKey="Jayaraman K" first="K." last="Jayaraman">K. Jayaraman</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Biotechnology, Anna University, Madras 600 025</wicri:regionArea><wicri:noRegion>Madras 600 025</wicri:noRegion></affiliation></author><author><name sortKey="Kaliraj, P" sort="Kaliraj, P" uniqKey="Kaliraj P" first="P." last="Kaliraj">P. Kaliraj</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>Centre for Biotechnology, Anna University, Madras 600 025</wicri:regionArea><wicri:noRegion>Madras 600 025</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Helminthology</title><title level="j" type="abbrev">J. Helminthol.</title><idno type="ISSN">0022-149X</idno><idno type="eISSN">1475-2697</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1997-09">1997-09</date><biblScope unit="volume">71</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="265">265</biblScope><biblScope unit="page" to="267">267</biblScope></imprint><idno type="ISSN">0022-149X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-149X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Helminth (isolation & purification)</term><term>Brugia malayi</term><term>Filariasis (immunology)</term><term>Humans</term><term>Immunity, Cellular</term><term>Interleukin-1 (secretion)</term><term>Lymphocyte Activation</term><term>Phytohemagglutinins (pharmacology)</term><term>T-Lymphocytes (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Antigènes d'helminthe (isolement et purification)</term><term>Brugia malayi</term><term>Filarioses (immunologie)</term><term>Humains</term><term>Immunité cellulaire</term><term>Interleukine-1 (sécrétion)</term><term>Lymphocytes T (immunologie)</term><term>Phytohémagglutinine (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filarioses</term><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Filariasis</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Phytohémagglutinine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Phytohemagglutinins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="secretion" xml:lang="en"><term>Interleukin-1</term></keywords><keywords scheme="MESH" qualifier="sécrétion" xml:lang="fr"><term>Interleukine-1</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brugia malayi</term><term>Humans</term><term>Immunity, Cellular</term><term>Lymphocyte Activation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Brugia malayi</term><term>Humains</term><term>Immunité cellulaire</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">An attempt was made to identify the filarial specific antigens that are capable of inducing immune response in human filariasis. Lymphocytes were taken from three clinically defined groups living in an endemic area in Madras, namely microfilaraemic (MF) subjects with microfilariae in their blood smear without any clinical symptoms, chronic pathology (CP) individuals with lymphangitis or lymphadenitis in combination with a history of recurrent filarial fevers or lymphoedema, and endemic normals (EN) subjects without microfilariae nor any clinical symptoms of pathology. Lymphocytes from the three groups responded with no significant difference (P = 0.21) in their proliferative index to PPD and PHA, although lymphocytes from MF individuals showed significantly (P < 0.001) less proliferative index to Brugia malayi antigen (BMA) than the CP and EN subjects. This antigen specific cellular unresponsiveness seen in MF patients was not reversed by the addition of recombinant IL-lα, IL-1β, and IFN-γ, but the addition of sera from EN individuals seemed to restore this unresponsiveness (P < 0.001). The peripheral blood mononuclear cells from MF patients secreted more IL-1 in response to BMA induction than the same from CP and EN individuals. A 58 kDa recombinant protein isolated from a Wuchereria bancrofti genomic library (58 kDa) had mounted a higher proliferative response to lymphocytes from all three groups compared to BMA (P < 0.001) indicating the possible use of recombinant filarial protein to mount immunological responses in filarial patients.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><country name="Inde"><noRegion><name sortKey="Regunathan, J" sort="Regunathan, J" uniqKey="Regunathan J" first="J." last="Regunathan">J. Regunathan</name></noRegion><name sortKey="Jayaraman, K" sort="Jayaraman, K" uniqKey="Jayaraman K" first="K." last="Jayaraman">K. Jayaraman</name><name sortKey="Kaliraj, P" sort="Kaliraj, P" uniqKey="Kaliraj P" first="P." last="Kaliraj">P. Kaliraj</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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